KEGS Biology Blog


Monday 21st January Section 2
January 21, 2013, 2:05 pm
Filed under: Uncategorized

Antibodies and immune response

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5 Comments so far
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Antibodies diagram with hinges, light chain, heavy chain, variable region, constant region and bonding site.

After first infection rise in concentration of IG due to colonal selection and expansion

The plasma cells turn into memory cells when this happens

The production of antibodies happens quicker and higher concentration after second infection

The memory cells turn into plasma cells

Colonial selection happens again

Happens quicker as memory cells allow quicker rate

Pathogens killed and plasma cells turned into memory cells again

Comment by nisithadissanayake

Secondary response has a higher concentration of Immunoglobulins as well as having a faster rate of response. Antibodies have four polypeptide chains held together by disulfide bridges – tertiary 3D structure.
Also there are two ways in which antibodies work: Blocking the binding sites of an antigen (neutralisation) and some antibodies have several y-shaped molecules with several variable regions, able to attach a number of pathogens, preventing them from entering a host cell (agglutination)

Comment by helenquah

I believe you made a mistake when you were talking about the B cells.

When cytokine is released, this stimulates the production of B cells (clonal selection)

Most of these B cells then differentiate into B plasma cells to deal with the pathogens however the rest differentiate into B memory cells with the same antibody information.

During secondary response, these memory cells then differentiate back into B cells and then into B plasma cells, as this is going on the immune system is producing more B cells itself, some of which would then become B memory cells.

B memory cells can differentiate into B plasma cells however it doesn’t work the other way around.

Comment by bensubhani

Discusses the structure of antibodies in considerable depth- really helped me visualise the new terms such as the light and heavy chains.

Comment by mehleen

Plasma cells release antibodies and last 2-3 days. Memory cells remembers the shape of the antibody required to bind with the pathogenic antigens. Lasts a long time and stay in the blood circulation. Differentiate back into plasma cells during 2nd infection.

Comment by candicetam




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